Dr. Khan is doing some incredible work with biologics and gene therapy. He thinks the prices will come down over time. It would be nice to get these therapies here and allow cartilage and joint regeneration without surgery. Imagine the benefits to society if a hip could be regenerated without surgery? Imagine prophylactic injections of biologics to prevent degenerative disk disease? The number of people who could be helped is astronomical.
Well the short answer is that in a free market prices go down over time. For the simple reason that you have to create more value for the buyer or else they don’t buy. So if we can get back to more of a free market the prices will come down over time. Jeff Booth does some great content around this.
The insulin prices go up because it’s not a free market. It’s a rigged market with rent seekers buying favor so they have the intermediaries that charge what they want. And if you check you’ll find the political contributions follow.
That sounds about right to me. I’m with you. From what I’m seeing Trump is doing things no one has ever dared to do. And he’s doing it quickly. Let’s see. It’s disgusting to see the system scammed at our expense.
The natural state of real free markets is one where prices go down. Having a central bank control the cost of money and government control an economy through taxation and regulation are the normal state of affairs we all experience. Jeff Booth does a good job explaining this. https://m.youtube.com/watch?v=0N6WRJsxX7U
The central planners want you to believe that Ita only safe when they are in charge. That’s not true. Taxes on income and investment are restrictions on private property rights. It distorts the market.
Presumably the gene therapy enthusiasts are already mutants from the safe and effective "vaccine". I'm sure this new gene therapy will be totally free of side effects. Enjoy
All I know is that God would not approve of this, therefore I won’t be doing it. Eat clean, fast, take cold baths, do lots of pull-ups…. You’ll be okay boys.
Usually free foreign DNA is destroyed by immune system within minutes. Even if it weren't, transformation or transfection of cells with plasmid DNA requires special chemical or physical stimulus, which makes membranes permeable for DNA and are harmful for healthy cells, so most of the cells die. And to make surviving cells produce a new gene in meaningful amounts, they must outcompete non-transfected ones.
All that being said, plasmid-based DNA vaccines are being developed. But the thing is that vaccines are targeting immune cells, which are rapidly dividing and differentiating all the time, so even if small percentage will be absorbed it'll be enough. Doing such trick with non-dividing muscle or other solid tissue cells and hoping for meaningful effect is hopeless and potentially dangerous because of autoimmune reaction.
Sure, I bet gene therapy can move your belly button about 20cm up.
The pictures are misleading.
Showing at least to me the referred post comes from someone ignorant, or not knowledgeable enough about the anatomy.
Which makes me very doubtful the Post comes from someone with knowledge or expertise in Medicine in a relevant manner to talk about gene therapy and “anatomical changes”.
That is exciting, but would be nice to see this proven out for a while before using it yourself!
Also, ever notice how the before/after pictures like the Follistatin images often feature someone that already has a very good muscular base, but needs to cut some fat to look truly impressive. Sort of like a body builder before a competition.
Dang. I was thinking about writing a science fiction story and one of the plot points was exactly this! (even the limited effect lifespan!) Science fiction no more…
Anyway, effects on fertility are of little concern for most people over 50.
Just like glasses and myopia, if gene editing becomes affordable we will build systems first to most effectively use the abilities of genetically edited people, then eventually dependent on genetically edited people, then eventually requiring everyone to get genetic interventions.
You will get insurance for you and your kids to go to a geneticist and get optimized genetic therapies to help you perform your duties most effectively
Dr. Khan is doing some incredible work with biologics and gene therapy. He thinks the prices will come down over time. It would be nice to get these therapies here and allow cartilage and joint regeneration without surgery. Imagine the benefits to society if a hip could be regenerated without surgery? Imagine prophylactic injections of biologics to prevent degenerative disk disease? The number of people who could be helped is astronomical.
Question: why would the prices come down? In America, that is. Explain in a way that also accounts for why insulin prices never go down.
Well the short answer is that in a free market prices go down over time. For the simple reason that you have to create more value for the buyer or else they don’t buy. So if we can get back to more of a free market the prices will come down over time. Jeff Booth does some great content around this.
The insulin prices go up because it’s not a free market. It’s a rigged market with rent seekers buying favor so they have the intermediaries that charge what they want. And if you check you’ll find the political contributions follow.
Maybe we'll see the backs of the pharma rent seekers broken soon. Otherwise I don't see prices coming down.
That sounds about right to me. I’m with you. From what I’m seeing Trump is doing things no one has ever dared to do. And he’s doing it quickly. Let’s see. It’s disgusting to see the system scammed at our expense.
Didn’t Trump remove the price cap on insulin drugs literally two weeks ago?
That’s true. That’s why free markets are deflationary. The competitor can offer better at lower prices. We don’t have that at the moment.
The natural state of real free markets is one where prices go down. Having a central bank control the cost of money and government control an economy through taxation and regulation are the normal state of affairs we all experience. Jeff Booth does a good job explaining this. https://m.youtube.com/watch?v=0N6WRJsxX7U
The central planners want you to believe that Ita only safe when they are in charge. That’s not true. Taxes on income and investment are restrictions on private property rights. It distorts the market.
Presumably the gene therapy enthusiasts are already mutants from the safe and effective "vaccine". I'm sure this new gene therapy will be totally free of side effects. Enjoy
I'll always scorn my mother for irreparably disfiguring my genes at age 14. No grandkids for you! Still love ya Mom, xoxo.
The quality and effects of these injections are variable so if you're healthy just assume it didn't do damage, forget about it and live your life.
Exciting, but not something I'd want to do first.
This technology is in its infancy, and is nowhere near ready for prime time.
Gene therapy just killed 17million people globally, and injured and disabled billions more.
They have no idea what they are doing.
All I know is that God would not approve of this, therefore I won’t be doing it. Eat clean, fast, take cold baths, do lots of pull-ups…. You’ll be okay boys.
whats the pricing on this stuff and how long before we get something that can increase my g factor to von neumann levels?
LOL nice bait for those who never opened a molecular biology textbook.
Can you elaborate? Curious how this post stacks up to knowledgeable scrutiny
Usually free foreign DNA is destroyed by immune system within minutes. Even if it weren't, transformation or transfection of cells with plasmid DNA requires special chemical or physical stimulus, which makes membranes permeable for DNA and are harmful for healthy cells, so most of the cells die. And to make surviving cells produce a new gene in meaningful amounts, they must outcompete non-transfected ones.
All that being said, plasmid-based DNA vaccines are being developed. But the thing is that vaccines are targeting immune cells, which are rapidly dividing and differentiating all the time, so even if small percentage will be absorbed it'll be enough. Doing such trick with non-dividing muscle or other solid tissue cells and hoping for meaningful effect is hopeless and potentially dangerous because of autoimmune reaction.
There are always side effects and trade offs. Aways.
Askenazi Jews have the some of the highest iq’s recorded but suffer much higher rates of mental illness.
My wife is of Viking ancestry and doesn’t fatigue in the gym but has high blood pressure from high hemoglobin levels.
I could go on but you get the point .
It’s true. I’m Indian and have a penchant for hailing Ubers and Lyfts that are basically just camels.
This is insane. I foresee gene therapy reports out of Hollywood following closely behind the heels of the Ozempic craze.
Sure, I bet gene therapy can move your belly button about 20cm up.
The pictures are misleading.
Showing at least to me the referred post comes from someone ignorant, or not knowledgeable enough about the anatomy.
Which makes me very doubtful the Post comes from someone with knowledge or expertise in Medicine in a relevant manner to talk about gene therapy and “anatomical changes”.
Hence probably useless, and likely harmful.
What are the odds they die earlier?
That is exciting, but would be nice to see this proven out for a while before using it yourself!
Also, ever notice how the before/after pictures like the Follistatin images often feature someone that already has a very good muscular base, but needs to cut some fat to look truly impressive. Sort of like a body builder before a competition.
Wonderful news. Thank you for sharing. I am saddened, but not surprised, by some of these other comments.
I would hope they are exploring cancer therapy via this technology?
Dang. I was thinking about writing a science fiction story and one of the plot points was exactly this! (even the limited effect lifespan!) Science fiction no more…
Anyway, effects on fertility are of little concern for most people over 50.
Just like glasses and myopia, if gene editing becomes affordable we will build systems first to most effectively use the abilities of genetically edited people, then eventually dependent on genetically edited people, then eventually requiring everyone to get genetic interventions.
You will get insurance for you and your kids to go to a geneticist and get optimized genetic therapies to help you perform your duties most effectively